The Sims laboratory develops experimental and computational tools for genomic analysis with applications in cancer biology, immunology, and neuroscience. Researchers in his lab apply these tools in many areas of biomedical research from the identification of cell type-specific drug responses in malignant brain tumors to the understanding tissue adaptation and function across immune cell lineages. Dr. Sims is also the Scientific Director of the Sulzberger Columbia Genome Center and co-directs the Precision Oncology and Systems Biology program in the Herbert Irving Comprehensive Cancer Center.